Using Genomic Sequencing to Treat Disease in the Horn of Africa 

Souad Elmi is an ISR community member and public health microbiologist who works in the National Reference Laboratory at Peltier General Hospital in Djibouti. She has experience in medical laboratory and public health initiatives, including infection control, epidemiology, antimicrobial stewardship, malaria, and tuberculosis (TB).  

She is passionate about using genomic sequencing to identify and treat the complicated diseases that plague her region in the Horn of Africa.

The International Science Reserve spoke to Souad about her goals to achieve health, sustainability, and well-being for all people. 

How did you get started in public health?  

My journey into public health and infection control began with my work as a medical laboratory scientist, where I witnessed the devastating impact of infectious diseases, particularly TB, HIV, which are complicated by antimicrobial resistance. Seeing patients suffer from preventable and treatable illnesses due to gaps in diagnostics and public health interventions motivated me to specialize in public health microbiology. My passion for health equity and disease prevention grew as I realized the urgent need for improved surveillance, diagnostics, and sustainable solutions to control infectious diseases in vulnerable populations, especially in the Horn of Africa. 

What projects are you currently working on?

Currently, I am working on molecular diagnostics related to TB in the National Reference Laboratory at Peltier General Hospital in Djibouti. My research focuses on drug resistance patterns and genomic sequencing to track TB strains and improve treatment strategies. Additionally, I am involved in antimicrobial stewardship initiatives, aiming to combat antibiotic resistance through laboratory-based surveillance and policy recommendations. These projects are crucial in strengthening disease control efforts and informing public health interventions in the region. 

Djibouti has one of the higher rates of tuberculosis in the world, but in recent years, the country has made efforts to reduce that number and close the gap. What have you seen as successful practices on this public health issue?  

Djibouti has made significant progress in TB control through enhanced case detection, rapid molecular diagnostics, and patient-centered treatment approaches. The introduction of GeneXpert technology, which allows for the detection of specific genetic material in a biological sample using a technique called nucleic acid amplification, has improved early detection of drug-resistant TB by reducing the time to acquiring diagnostic results from weeks to hours. Community-based interventions have increased treatment adherence by patients. Strengthening laboratory capacity and integrating TB care with HIV services have also played a vital role in reducing TB incidence. However, investment in genomic surveillance, social support programs, and health system strengthening is essential to further close the gap. 

What more could scientists be doing to work together on persistent public health issues that you study, like malaria and tuberculosis?  

Scientists need to foster greater collaboration in genomic research, data sharing, and interdisciplinary approaches to tackling infectious diseases. Strengthening regional laboratory networks, expanding access to sequencing technologies, and integrating artificial intelligence for disease surveillance can significantly enhance early detection and response efforts. Additionally, partnerships between researchers, policymakers, and local communities are crucial to developing sustainable solutions that address both biomedical and social determinants of health. Investing in capacity-building and mentorship programs will also empower young scientists in resource-limited settings to contribute meaningfully to public health advancements. 

Why did you join the ISR, and why would you encourage others to join too? 

I joined the ISR because I believe in the power of scientific collaboration to address global health crises, particularly in regions facing resource constraints. Being part of an international network allows me to engage with experts from diverse fields, access cutting-edge research, and contribute to global preparedness efforts for emerging diseases. I encourage others to join ISR to collaborate on innovative solutions, share expertise, and strengthen scientific resilience in the face of complex public health challenges. Together, we can drive impactful change and improve health outcomes worldwide.